I’m currently taking Spironolactone, an antibiotic every morning, and birth control at night (Tri-Sprintec). The combination of birth control and Spiro is supposed to be more effective at preventing acne than either one is on its own. Based on the results I’m having I would have to agree with this. I’ve been on birth control for over a year and wouldn’t say it’s had much effect on reducing or keeping my acne at bay. As soon as I added Spiro to the mix my breakouts almost completely stopped, no more annoying whiteheads popping up all over my face every morning (I still get a few on occasion but nothing like I use to). My face has been the clearest it’s been in a long time. The only issue I’m having is occasionally increased redness from using Tretinoin due to my sensitive skin. I’ve been lucky enough not to experience a purging phase from the Tretinoin, or at least it hasn’t happened yet. Fingers crossed. I do have pick scars from acne that I’m hoping the Tretnion will reduce. There’s a noticeable improvement in my skin’s texture and color and it’s only been one month.